Benchmarks for antiretroviral therapy

Benchmarks for antiretroviral therapy.

Antiretroviral Therapy for HIV Infection

The HIV/AIDS is now twenty five years old and, in these 25 years, more than 60 million people have been infected by human immunodeficiency virus (HIV). As on December 2006, nearly 39.5 million people globally are living with HIV/AIDS1. During this period, lot of efforts have gone into understanding the structure of viruses, its molecular biology and the pathogenesis of disease. The information ...

Derivation of parameters used in Spectrum for eligibility for antiretroviral therapy and survival on antiretroviral therapy

BACKGROUND The Spectrum projection package uses estimates of national HIV incidence, demographic data and other assumptions to describe the consequences of the HIV epidemic in low and middle-income countries. The default parameters used in Spectrum are updated every 2 years as new evidence becomes available to inform the model. This paper reviews the default parameters that define the course of...

Guidelines for antiretroviral therapy for HIV infection

Objective: To develop guidelines for health care providers and their HIV-positive patients on the clinical use of antiretroviral agents for HIV infection. Options: Recommendations published in 1996 by an international panel. Outcomes: Improvement in clinical outcomes or in surrogate markers of disease activity. Evidence and values: The Canadian HIV Trials Network held a workshop on Oct. 19–20, ...

Optimizing Antiretroviral Therapy

The data guiding the dosing, efficacy and safety of medicines for children have lagged substantially as compared to the information available for adults. As a consequence, pediatricians faced with the prospect of confining their practice to medicines with adequate information have frequently resorted to prescribing medicines for unapproved uses (different dose, frequency, age group, route, indi...